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Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet
Authors:Kunimoto Koshi  Yamazaki Yuji  Nishida Tomoki  Shinohara Kyosuke  Ishikawa Hiroaki  Hasegawa Toshiaki  Okanoue Takeshi  Hamada Hiroshi  Noda Tetsuo  Tamura Atsushi  Tsukita Shoichiro  Tsukita Sachiko
Institution:1. Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan;2. Research Center for Ultra-high Voltage Electron Microscopy, Osaka University, Osaka 567-0047, Japan;3. Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University and CREST, Japan Science and Technology Corporation (JST), Osaka 565-0871, Japan;4. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA;5. Department of Hepatology, Saiseikai Suita Hospital, Osaka 564-0013, Japan;6. Department of Cell Biology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan;7. Department of Cell Biology, Faculty of Medicine, Kyoto University, Yoshida-Konoe, Kyoto 606-8315, Japan
Abstract:
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  • Highlights? Mice expressing truncated Odf2 cough and sneeze due to primary ciliary dyskinesia ? Full-length Odf2 is needed for the formation of basal body-associated basal feet ? In the absence of basal feet, basal bodies fail to align with planar polarity cues ? Polarization of basal bodies by Odf2 is required for coordinated ciliary beating
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