Lymphocyte adherence in multiple sclerosis: Lack of virus specificity |
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| Authors: | Paula Dore-Duffy Robert B Zurier |
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| Institution: | 1. Division of Neuroimmunology, Department of Neurology, University of Connecticut School of Medicine, Farmington, Connecticut 06032 U.S.A.;2. Rheumatology Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A. |
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| Abstract: | The virus specificity of adherence of peripheral blood mononuclear leukocytes from patients with multiple sclerosis and from age- and sex-matched healthy volunteers to tissue culture cells infected with measles virus, Newcastle disease virus, and vesicular stomatitis virus was studied. Lymphocyte adherence to uninfected cells is uniformly low (5–15% tissue culture cells with > 3 lymphocytes adhered). Adherence to cells infected with virus is enhanced 2- to 4-fold in controls and 2- to 10-fold in patients with multiple sclerosis. Virus-specific antigen, antiserum, and receptor, at least in part, inhibited adherence to all cells tested. It is concluded from these studies that increased lymphocyte adherence in multiple sclerosis is not measles virus specific. |
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| Keywords: | To whom requests for reprints should be addressed |
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