Microsome-mediated mutagenicities of the dihydrodiols of 7,12-dimethylbenz[a]anthracene: high mutagenic activity of the 3,4-dihydrodiol. |
| |
| Authors: | C Malaveille H Bartsch B Tierney P L Grover P Sims |
| |
| Affiliation: | Unit of Chemical Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France;Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, London SW3 6JB, England |
| |
| Abstract: | 7,12-Dimethylbenz[a]anthracene and its 3,4-, 5,6-, 8,9- and 10,11-dihydrodiols have been tested for mutagenicity towards . TA100 in the presence of rat-liver post-mitochondrial supernatants from Aroclor-treated rats. At non-toxic concentrations, the non-K-region 3,4-dihydrodiol was six-fold more active than the parent hydrocarbon. At these concentrations, the 8,9-dihydrodiol showed some mutagenic activity, but the 5,6- and 10,11-dihydrodiols were inactive. |
| |
| Keywords: | To whom correspondence and reprint requests should be addressed |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
