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The collaborative study on the genetics of alcoholism: Genetics |
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| Authors: | Emma C Johnson Jessica E Salvatore Dongbing Lai Alison K Merikangas John I Nurnberger Jay A Tischfield Xiaoling Xuei Chella Kamarajan Leah Wetherill COGA Collaborators John P Rice John R Kramer Samuel Kuperman Tatiana Foroud Paul A Slesinger Alison M Goate Bernice Porjesz Danielle M Dick Howard J Edenberg Arpana Agrawal |
| Institution: | 1. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA;2. Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA;3. Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA;4. Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA;5. Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA;6. Department of Genetics, Rutgers University, Piscataway, New Jersey, USA;7. Department of Psychiatry and Behavioral Sciences, State University of New York Health Sciences University, Brooklyn, New York, USA;8. Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA;9. Departments of Neuroscience and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA;10. Departments of Genetics and Genomic Sciences, Neuroscience, and Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA;11. Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis, Indiana, USA |
| Abstract: | This review describes the genetic approaches and results from the family-based Collaborative Study on the Genetics of Alcoholism (COGA). COGA was designed during the linkage era to identify genes affecting the risk for alcohol use disorder (AUD) and related problems, and was among the first AUD-focused studies to subsequently adopt a genome-wide association (GWAS) approach. COGA's family-based structure, multimodal assessment with gold-standard clinical and neurophysiological data, and the availability of prospective longitudinal phenotyping continues to provide insights into the etiology of AUD and related disorders. These include investigations of genetic risk and trajectories of substance use and use disorders, phenome-wide association studies of loci of interest, and investigations of pleiotropy, social genomics, genetic nurture, and within-family comparisons. COGA is one of the few AUD genetics projects that includes a substantial number of participants of African ancestry. The sharing of data and biospecimens has been a cornerstone of the COGA project, and COGA is a key contributor to large-scale GWAS consortia. COGA's wealth of publicly available genetic and extensive phenotyping data continues to provide a unique and adaptable resource for our understanding of the genetic etiology of AUD and related traits. |
| Keywords: | alcohol use disorder (AUD) alcoholism family-based studies genetic nurture genome-wide association study (GWAS) longitudinal studies polygenic scores (PGS) prospective studies substance-related disorders within-family comparisons |