白细胞介素13及其研究进展

白细胞介素13(IL-13)是最近被发现的一种新型细胞因子,由激活的辅助T细胞产生,其分泌产物主要是一种分子量约为10000的非糖基化的单链蛋白.人和鼠IL-13成熟蛋白分别由112和111个氨基酸残基组成,IL-13不仅对单核细胞的体外生长、表面抗原表达以及多种细胞因子的产生具有明显的调控作用,而且对B细胞的增殖、分化以及免疫球蛋白合成同样具有调控作用.更引人注目的是,在造血祖细胞的增植分化调控中,IL-13与其他造血生长因子有协同作用.

Progress on the Study of Interleukin 13

Interleukin 13(IL-13)is a recently described novel cytokine produced by activated helper T cells. IL-13 protein is secreted mainly in unglycosylated form with molecular mass of about 10 ku.The mature ILs-13 of human and mouse consist of 112 and 111 amino acid residues respectively.IL-13 not only regulates the growth,surface antigen expression,and cytokine production of monocytes,but also regulates its proliferation,Ig isotype switching,and Ig synthesis of B cells.Furthermore,IL-13 synergizes with other hematopoietic growth factors in regulating proliferation and differentiation of primitive hematopoietic progenitor cells.