Semi-synthetic nucleic acid-protein conjugates: applications in life sciences and nanobiotechnology |
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Authors: | Niemeyer C M |
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Institution: | Universit?t Bremen, FB2-UFT, Biotechnologie und Molekulare Genetik, Germany. cmn@uni-bremen.de |
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Abstract: | Semi-synthetic conjugates of nucleic acids and proteins can be generated by either covalent coupling chemistry, or else by non-covalent biomolecular recognition systems, such as receptor-ligands of complementary nucleic acids. These nucleic acid-protein conjugates are versatile molecular tools which can be applied, for instance, in the self-assembly of high-affinity reagents for immunological detection assays, the fabrication of laterally microstructured biochips containing functional biological groups, and the biomimetic 'bottom-up' synthesis of nanostructured supramolecular devices. This review summarizes the current state-of-the-art synthesis and characterization methods of artificial nucleic acid-protein conjugates, as well as applications and perspectives for future developments of such hybrid biomolecular components in life sciences and nanobiotechnology. |
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