CD19 regulates ADAM28‐mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells |
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| Authors: | Yu Zhang Gaizhi Zhu He Xiao Xiaoling Liu Gencheng Han Guojiang Chen Chunmei Hou Beifen Shen Yan Li Ning Ma Renxi Wang |
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| Affiliation: | 1. Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China;2. College of Pharmacy, Henan University, Kaifeng, China;3. Laboratory of Cellular and Molecular Immunology, Henan University, Kaifeng, Henan, China;4. Department of Nephrology, The 307th Hospital of Chinese People's Liberation Army, Beijing, China;5. Department of Rheumatology, First Hospital of Jilin University, Changchun, China |
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| Abstract: | As the first line of defence, marginal zone (MZ) B cells play principal roles in clearing blood‐borne pathogens during infection and are over‐primed in autoimmune diseases. However, the basic mechanisms underlying MZ B‐cell development are still unclear. We found here that CD19 deficiency blocked the differentiation of marginal zone precursors (MZP) to MZ B cells, whereas CD19 expression in CD19‐deficient MZP rescues MZ B‐cell generation. Furthermore, CD19 regulates Notch2 cleavage by up‐regulating ADAM28 expression in MZP. Finally, we found that CD19 suppressed Foxo1 expression to promote ADAM28 expression in MZP. These results suggest that CD19 controls the differentiation of MZP to MZ B cells by regulating ADAM28‐mediated Notch2 cleavage. Thus, we demonstrated the basic mechanisms underlying the differentiation of MZP to MZ B cells. |
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| Keywords: | CD19 marginal zone precursors MZ B cells Notch2 ADAM28 Foxo1 |
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