The multidrug resistance protein family |
| |
| Authors: | Borst P Evers R Kool M Wijnholds J |
| |
| Affiliation: | Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. pborst@nki.nl |
| |
| Abstract: | The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6. In this review, we summarize what is known about the protein structure, the expression in tissues, the routing in cells, the physiological functions, the substrate specificity, and the role in multidrug resistance of the individual members of the MRP family. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
