Heterogeneity in the map distance between X-linked agammaglobulinemia and a map of nine RFLP loci |
| |
| Authors: | J. Ott E. J. B. M. Mensink A. Thompson J. D. L. Schot R. K. B. Schuurman |
| |
| Affiliation: | (1) Department of Psychiatry, Columbia University, 722 West 168th Street, 10032 New York, NY, USA;(2) Division of Immunobiology, Department of Immunohaematology, University Medical Center, P. O. Box 9600, NL-2300 RC Leiden, The Netherlands |
| |
| Abstract: | Summary In nine family pedigrees in which X-linked agammaglobulinemia (XLA) is segregating, a multi-point linkage analysis has been carried out. In each family, the map distance, d, between XLA and a fixed point in a known map of nine RFLP loci on the X chromosome was estimated by calculating the log likelihoods, L(d). Using a new method, the 10-point likelihood was approximated by appropriately combining three 4-point likelihoods. Homogeneity tests (admixture tests) were performed showing clear evidence for heterogeneity of XLA. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
