Bifunctional 2-naphthyl propargylic sulfones exhibiting high DNA intercalating and alkylating activity. |
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| Authors: | W M Dai C W Chow L Zhou A Ishii C W Lau Q Li W Hamaguchi S Nishimoto |
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| Affiliation: | Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, China. |
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| Abstract: | A number of novel 2-naphthyl propargylic sulfones were synthesized as nucleic base alkylating agents. Extremely high DNA cleavage activity was observed for the sulfones with a free omega-hydroxyl group in the carbon chain in contrast to the ester conjugates possessing an additional intercalating unit. |
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