The role of leptin in the control of the expression of activation membrane molecules by different T-cell subpopulations |
| |
Authors: | E. G. Orlova S. V. Shirshev |
| |
Affiliation: | (1) Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081, Russia |
| |
Abstract: | The effect of leptin at doses characteristic of pregnancy on the expression of activation markers of different T-cell subpopulations of peripheral blood of women was studied. It was found that the hormone decreases CD25 expression on activated T-helpers and increases it on cytotoxic T cells but has no effect on the number of CD95+ T-cells and T regulatory cells. In interleukin-2-stimulated cells, the effects of leptin change for the opposite: the hormone does not affect CD25 expression on activated T-helpers and suppresses it on CD8+ T cells. Thus, it is shown that leptin plays a key role in the activation of T cells during pregnancy. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|