Release of distal gut peptide YY (PYY) by fat in proximal gut depends on CCK |
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Authors: | Lin H C Chey W Y Zhao X |
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Institution: | Department of Medicine, Burns & Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. henry.lin@cshs.org |
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Abstract: | We tested the hypothesis that the release of PYY by fat confined to the proximal small intestine is dependent on CCK. Using a multi-fistulated model, plasma PYY levels were compared in 6 dogs after 60 mM oleate was perfused into the proximal one-half of the small intestine following i.v. administration of saline or devazepide, a CCK-A antagonist. Plasma PYY increased with fat (P < 0. 05), but plasma PYY level was lower following devazepide at 60 min and 90 min (P < 0.05). We conclude that CCK serves as a foregut signal linking fat in the proximal gut with the release of distal gut PYY. |
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