Impact of Carrier Systems on the Interactions of Coenzyme Q10 with Model Lipid Membranes |
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Authors: | Ajda Ota Marjeta Šentjurc Marjan Bele Pegi Ahlin Grabnar Nataša Poklar Ulrih |
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Affiliation: | 1.Biotechnical Faculty,University of Ljubljana,Ljubljana,Slovenia;2.Institute “Jo?ef Stefan”,Ljubljana,Slovenia;3.National Institute of Chemistry Slovenia,Ljubljana,Slovenia;4.Faculty of Pharmacy,University of Ljubljana,Ljubljana,Slovenia |
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Abstract: | We investigated the influence of carrier systems for different commercially available water-soluble formulations for coenzyme Q10 on structural changes of model lipid membranes formed by 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and by a mixture of phosphatidylcholine and sphingomyelin (2.4:1). Structural changes in the membranes were measured using fluorescence anisotropy, electron paramagnetic resonance, and differential scanning calorimetry. Two fluorophores and two spin probes were used to monitor membrane characteristics close to the water-lipid interface and in the middle of the bilayer of the model lipid membranes. Different water-soluble carrier systems were tested. These data show that different systems can facilitate penetration of CoQ10 in the lipid membranes, where an increase in the lipid order parameter was observed. In addition, water soluble CoQ10 formulations better protect lipids from oxidation in liposome solution. With the exception of the carriers in an emulsified formulation of CoQ10, those in the other samples did not have any significant effects on membrane fluidity. |
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