Erroneous synthesis of ribosomal proteins in amino acid starved E. coli |
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Authors: | E Andrieux E Robert A J Cozzone |
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Institution: | Laboratory of Molecular Biology, University of Lyon, 43 Bd. du Onze Novembre, 69622 Villeurbanne, France |
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Abstract: | The effect of amino acid starvation on the accuracy of translation of ribosomal proteins was analyzed in a stringent (relA+)/relaxed (relA) pair of E. coli strains. The degree of misreading was estimated from the amount of cysteine erroneously incorporated into individual proteins during arginine starvation of bacteria. Illegitimate incorporation of cysteine was found to occur to a significant extent in several proteins from both the small and the large subunits of ribosomes, in either type of strain. |
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