Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant <Emphasis Type="Italic">Borrelia garinii</Emphasis> OspA serotype 4期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4

Authors:	Nathalie D van Burgel Peter Kraiczy Tim J Schuijt Peter F Zipfel Alje P van Dam

Affiliation:	(1) Department of Medical Microbiology, Centre of Infectious Diseases, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, the Netherlands;(2) Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Paul-Ehrlich-Str. 40, D-60596 Frankfurt, Germany;(3) Department of Infection Biology, Leibniz-Institute for Natural Products Research, Beutenbergstr.11a, 07745 Jena, Germany

Abstract:	Background B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. Spirochetes have adapted themselves to the human immune system in many distinct ways. One important immune escape mechanism for evading complement activation is the binding of complement regulators Factor H (CFH) or Factor H-like protein1 (FHL-1) to Complement Regulator-Acquiring Surface Proteins (CRASPs).

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