Systems-level analysis of gene expression data revealed NR0B2/SHP as potential tumor suppressor in human liver cancer |
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Authors: | Yun-Yong Park Hueng-Sik Choi Ju-Seog Lee |
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Institution: | (1) Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA; |
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Abstract: | Nuclear receptors (NRs) play pivotal roles in cell growth, proliferation, differentiation and homeostasis. Recent progress
demonstrates that NR is tightly linked to human disease such as cancer, diabetes and obesity. Here we explore NR expression
profiles in human tissue using systematic approaches. NR gene profiles reveal that individual NR has its own gene expression
signature depending on tissue type. Of many organs, NRs expression is enriched in liver. Expression of many NRs was significantly
changed in liver cancer. Notably, NR0B2/SHP expression level was significantly decreased in human liver cancer but not in normal liver. In addition, expression of SHP
is well associated with good prognosis. SHP gene network analysis based on microarray data in liver cancer shows that SHP
regulates cell proliferation and metabolism related gene sets. Our systematic approaches suggest that loss of SHP expression
in liver might be key genetic events during hepatocarcinogenesis. |
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