Beneficial Effects of Minocycline on Cuprizone Induced Cortical Demyelination |
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Authors: | Thomas Skripuletz Elvira Miller Darius Moharregh-Khiabani Alexander Blank Refik Pul Viktoria Gudi Corinna Trebst Martin Stangel |
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Institution: | (1) Department of Neurology, Hannover Medical School, Carl-Neuberg-Str-1, 30625 Hanover, Germany;(2) Center for Systems Neuroscience, Hannover, Germany; |
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Abstract: | In this study, we investigated the potential of minocycline to influence cuprizone induced demyelination in the grey and white
matter. To induce demyelination C57BL/6 mice were fed with cuprizone for up to 6 weeks and were analysed at different timepoints
(week 0, 4, 5, 6). Mice treated with minocycline had less demyelination of the cortex and corpus callosum compared with sham
treated animals. In the cortex decreased numbers of activated and proliferating microglia were found after 6 weeks of cuprizone
feeding, while there were no significant effects for microglial infiltration of the corpus callosum. In addition to the beneficial
effects on demyelination, minocycline prevented from motor coordination disturbance as shown in the beam walking test. For
astrogliosis and the numbers of OPC and oligodendrocytes no treatment effects were found. In summary, minocycline treatment
diminished the course of demyelination in the grey and white matter and prevented disturbances in motor coordination. |
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