Neuronal MHC Class I Molecules are Involved in Excitatory Synaptic Transmission at the Hippocampal Mossy Fiber Synapses of Marmoset Monkeys |
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Authors: | Adema Ribic Mingyue Zhang Christina Schlumbohm Kerstin Mätz-Rensing Barbara Uchanska-Ziegler Gabriele Flügge Weiqi Zhang Lutz Walter Eberhard Fuchs |
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Institution: | 1.Clinical Neurobiology Laboratory,German Primate Center, Leibniz Institute for Primate Research,G?ttingen,Germany;2.Primate Genetics Laboratory,German Primate Center, Leibniz Institute for Primate Research,G?ttingen,Germany;3.Infection Pathology Unit,German Primate Center, Leibniz Institute for Primate Research,G?ttingen,Germany;4.Department of Neurology,Medical School, Georg-August-University,G?ttingen,Germany;5.DFG Research Center Molecular Physiology of the Brain (CMPB),G?ttingen,Germany;6.Laboratory of Molecular Psychiatry, Department of Psychiatry,Westf?lische Wilhelms University,Münster,Germany;7.Institut für Immungenetik, Charité-Universit?tsmedizin Berlin,Berlin,Germany |
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Abstract: | Several recent studies suggested a role for neuronal major histocompatibility complex class I (MHCI) molecules in certain
forms of synaptic plasticity in the hippocampus of rodents. Here, we report for the first time on the expression pattern and
functional properties of MHCI molecules in the hippocampus of a nonhuman primate, the common marmoset monkey (Callithrix jacchus). We detected a presynaptic, mossy fiber-specific localization of MHCI proteins within the marmoset hippocampus. MHCI molecules
were present in the large, VGlut1-positive, mossy fiber terminals, which provide input to CA3 pyramidal neurons. Furthermore,
whole-cell recordings of CA3 pyramidal neurons in acute hippocampal slices of the common marmoset demonstrated that application
of antibodies which specifically block MHCI proteins caused a significant decrease in the frequency, and a transient increase
in the amplitude, of spontaneous excitatory postsynaptic currents (sEPSCs) in CA3 pyramidal neurons. These findings add to
previous studies on neuronal MHCI molecules by describing their expression and localization in the primate hippocampus and
by implicating them in plasticity-related processes at the mossy fiber–CA3 synapses. In addition, our results suggest significant
interspecies differences in the localization of neuronal MHCI molecules in the hippocampus of mice and marmosets, as well
as in their potential function in these species. |
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