The regulation of INK4/ARF in cancer and aging |
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| Authors: | Kim William Y Sharpless Norman E |
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| Institution: | Department of Medicine, The University of North Carolina School of Medicine, Chapel Hill, 27599, USA. |
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| Abstract: | Loss of the INK4a/ARF/INK4b locus on chromosome 9p21 is among the most frequent cytogenetic events in human cancer. The products of the locus--p15(INK4b), p16(INK4a), and ARF--play widespread and independent roles in tumor suppression. Recent data also suggest that expression of p16(INK4a) induces an age-dependent decrease in the proliferative capacity of certain tissue-specific stem cells and unipotent progenitors. Here, we discuss the regulation and role of p16(INK4a), ARF, and p15(INK4b) in cancer and aging. |
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