桂枝汤对胃H，K－ATP酶活力的影响及对消炎痛引起胃H，K－ATP酶抑制作用的保护

中药桂枝汤在整体水平上能极其显著的激活胃Ｈ，Ｋ－ＡＴＰ酶的活力，而离体水平上对该酶呈现明显抑制效应。消炎痛在整体和离体水平上均对胃Ｈ，Ｋ－ＡＴＰ酶呈现抑制作用。桂枝汤在整体水平上对消炎痛引起胃Ｈ，Ｋ－ＡＴＰ酶的抑制作用有保护效应。这些结果提示桂枝汤可能通过机体整体调节实现其提高胃Ｈ，Ｋ－ＡＴＰ酶活力作用的，从而在Ｈ，Ｋ－ＡＴＰ酶水平上初步阐述了中药桂枝汤调整胃功能的可能作用机理。而且也为扩充桂枝汤的应用范围提供了可能性。

The Effect of GUIZHITANG on the Activity of Gastric H, K-ATPase and the preventive Effect of GUIZHITANG on Indomethacin-Induced Inhibition of the Gastric H, K-ATPase from Rats

GUIZHITANG is a traditional chinese medicine. In vivo, significantly activated effect of GUIZHITANG on the gastric H, K-ATPase was observed. But in vitro, GUIZHITANG showed an inhibitory effect. Both in vivo and in vitro, the indomathacin showed inhibitory effect on the H, K-ATPase. And the GUIZHITANG could obviously prevent the indomethacin-induced inhibition of H, K-ATPase. The results suggested that the activation effect of GUIZHITANG on the H, K-ATPase could be exerted through a complicated regulation in vivo and that the mechanism for regulation of digestive function by GUIZHITANG could be elucidated in H, K-ATPase level.