Ultrastructural observations of granule extrusion from rat anterior pituitary cells after injection of LH-releasing hormone |
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| Authors: | M. Shiino A. Arimura A. V. Schally E. G. Rennels |
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| Affiliation: | (1) Department of Anatomy, The University of Texas Medical School at San Antonio, San Antonio, Texas, U.S.A.;(2) Endocrine and Polypeptide Laboratories, Veterans Administration Hospital and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, U.S.A. |
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| Abstract: | Summary In order to observe the ultrastructural aspects of granule extrusion from gonadotrophs, the authors injected pure, natural porcine LH-releasing hormone (LH-RH) into persistent-estrous (PE) rats. Clear-cut extrusions of secretory granules appeared from LH-gonadotrophs 2.5, 5 and 15 minutes after the injection. Massive extrusion was observed at 15 minutes. Serum LH and FSH were also estimated by radioimmunoassay on blood samples taken at the same times after the injections. LH was increased in the blood sera after the injection of LH-RH, but serum FSH was not significantly different among the various treated rats. The rise in serum LH after LH-RH injection was well correlated with the ultrastructural phenomenon of granule extrusion from LH-gonadotrophs.The study was supported by USPHS Grants AM 12583, AM 09094 and AM 07467.The authors acknowledge the able assistance of Mrs. Martha Castilleja in San Antonio and of Meredith M. Nickel in New Orleans. |
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| Keywords: | Rat pituitary gland Ultrastructure Granule extrusion LH-releasing hormone |
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