Relationship between power law coefficients and major blood constituents affecting the whole blood viscosity |
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Authors: | Mohammad A Hussain Subir Kar Ram R Puniyani |
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Institution: | (1) School of Biomedical Engineering, Indian Institute of Technology Bombay, 400 076 Mumbai, India |
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Abstract: | The present work concerns a quantitative analysis of parameters that affect apparent blood viscosity at different low shear
rates, i.e, between 1 s−1 and, 100 s−1. Viscosity profile of a large number of blood samples from thromboembolic stroke cases and age and sex matched healthy controls
were studied which confirmed non-Newtonian power law behaviour of blood. The power law coefficients,n andk, which are unique to each blood sample, were related with blood viscosity parameters in the form of a mathematical equation
by performing non-linear regression analysis. It was possible to calculaten andk of power law model by supplying the values of major blood constituents in the equation obtained for stroke and controls.
The calculation ofn andk of a blood sample using the equation obtained, provided a quick information on its apparent viscosity values at any given
shear rate without viscometry. The calculated and the experimental viscosity were found in good agreement within a permissible
error range. The relation obtained between power law coefficients and major blood constituents in the present investigation
would give a quantification of different blood viscosity parameters contributing to the resistance to flow of blood. Such
an analysis may be considered as a scientific basis for the study of blood fluidity in different disease conditions. |
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Keywords: | Cerebrovascular accidents (CVA) blood viscosity power law haematocrit fibrinogen cholesterol |
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