An unusual Alu repeat sequence within the CAD gene |
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Authors: | Jeffrey N Davidson Nada H Khattar Kuey-Chu Chen |
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Institution: | (1) Department of Microbiology and Immunology, University of Kentucky, Albert B. Chandler Medical Center, 40536-0084 Lexington, Kentucky, USA |
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Abstract: | Summary There are several hundred thousand members of the Alu repeat family in the human genome. Those Alu elements sequenced to date
appear to fit into subfamilies. A novel Alu has been found in an intron of the human CAD gene: it appears to be due to rearrangement
between Alu repeats belonging to two different subfamilies. Further sequence data from this intron suggest that the Alu element
may have rearranged prior to its entry into the CAD gene. Such findings indicate that, in addition to single nucleotide substitutions
and deletions, DNA rearrangments may be a factor in generating the diversity of Alu repeats found in primate genomes. |
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Keywords: | Alu family evolution Subfamily rearrangement |
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