Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study |
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Authors: | Rita Dreier Kurt Werner Schmid Volker Gerke K Riehemann |
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Institution: | (1) Gerhard-Domagk-Institute of Pathology, Domagkstrasse 17, D-48149 Münster, Germany, DE;(2) Centre for Molecular Biology of Inflammation, Institute for Medical Biochemistry, von-Esmarchstrasse 56, D-48149 Münster, Germany e-mail riehema@uni-muenster.de Tel. +49–251–83–56722; fax +49–251–83–56748, DE |
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Abstract: | Annexins constitute a family of Ca2+- and phospholipid-binding proteins. Although their functions are still not clearly defined, several members of the annexin
family have been implicated in membrane-related events along exocytotic and endocytotic pathways. To elucidate a possible
correlation of those functional proposals with the tissue distribution of annexins, we analysed immunohistochemically the
expression of annexins I, II and IV in a broad variety of human tissues. Annexins I and II were chosen for this study since
their functionally relevant N-terminal domains are structurally closely related, whilst annexin IV is structurally less related
to the former two proteins. The study revealed distinct expression patterns of annexins I, II and IV throughout the body.
Annexin I was found in leucocytes of peripheral blood, tissue macrophages and T-lymphocytes and in certain epithelial cells
(respiratory and urinary system, superficial cells of non-keratinised squamous epithelium), annexin II in endothelial cells,
myoepithelial cells and certain epithelial cells (mainly respiratory and urinary system), whereas annexin IV was almost exclusively
found in epithelial cells. Epithelia of the upper respiratory system, Bowman’s capsule, urothelial cells, mesothelial cells,
peripheral nerves, the choroid plexus, ependymal cells and pia mater and arachnoid of meninges generally strongly expressed
all three annexins investigated. The characteristic expression in different tissues and the intracellular distribution indicates
that the three annexins investigated are involved in aspects of differentiation and/or physiological functions specific to
these tissues.
Accepted: 15 January 1998 |
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