| LC-MS导向分离山壳骨中主成分及其生物活性研究 |
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| 引用本文： | 吴浩祥,袁捷,肖文静,陈锦兰.LC-MS导向分离山壳骨中主成分及其生物活性研究[J].热带亚热带植物学报,2019,27(2):208-212. |
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| 作者姓名： | 吴浩祥 袁捷 肖文静 陈锦兰 |
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| 作者单位： | 广州中医药大学第一附属医院, 广州 510405,广州中医药大学中医药数理工程研究院, 广州 510006,广州中医药大学中医药数理工程研究院, 广州 510006,广州中医药大学中医药数理工程研究院, 广州 510006 |
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| 基金项目： | 广东省中药新药研发重点实验室开放运行费（2017B030314096）资助 |
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| 摘 要： | 为了解山壳骨(Pseuderanthemum latifolium)的化学成分和生物活性,运用LC-MS联用技术分离得到羽扇豆醇(1)和豆甾醇(2)。体外活性评价结果表明,化合物1和2均具有中等的抗MRSA活性,但不具有神经保护作用。这是首次对山壳骨进行化学成分和生物活性研究,为综合开发与利用山壳骨提供科学依据。
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| 关 键 词： | 山壳骨 LC-MS 羽扇豆醇 豆甾醇 |
| 收稿时间： | 2018/11/22 0:00:00 |
| 修稿时间： | 2018/12/20 0:00:00 |
LC-MS Guided Isolation of Chemical Constituents from Pseuderanthemum latifolium and Their Biological Activities |
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| WU Hao-xiang,YUAN Jie,XIAO Wen-jing and CHEN Jin-lan.LC-MS Guided Isolation of Chemical Constituents from Pseuderanthemum latifolium and Their Biological Activities[J].Journal of Tropical and Subtropical Botany,2019,27(2):208-212. |
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| Authors: | WU Hao-xiang YUAN Jie XIAO Wen-jing and CHEN Jin-lan |
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| Institution: | The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China,Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China,Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China and Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China |
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| Abstract: | In order to study the chemical constituents from Pseuderanthemum latifolium and their biological activities, two main compounds were isolated from the EaOAc fraction and identified as lupeol (1) and stigmasterol (2) by using LC-MS guided isolation. In vitro activity screening, all these compounds showed moderate anti-MRSA activities but no neuroprotective effects. This is the first report about the chemical constituents from P. latifolium and their biological activities, which would provide scientific basis to the development and utilization of P. latifolium. |
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| Keywords: | Pseuderanthemum latifolium LC-MS Lupeol Stigmasterol |
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