Development of associations among central adiposity, adiponectin and insulin sensitivity from adolescence to young adulthood |
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| Authors: | Rasmussen-Torvik L J Pankow J S Jacobs D R Steinberger J Moran A Sinaiko A R |
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| Affiliation: | Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA Department of Nutrition, University of Oslo, Oslo, Norway Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. |
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| Abstract: | Diabet. Med. 29, 1153-1158 (2012) ABSTRACT: Objective To examine associations of central adiposity, serum adiponectin and clamp-derived insulin sensitivity in a single longitudinal cohort from early adolescence to young adulthood. Methods The cohort was examined three times at mean ages 15?years (n?=?308), 19?years (n?=?218) and 22?years (n?=?163). Insulin sensitivity was measured with the euglycaemic hyperinsulinaemic clamp. Circulating adiponectin was measured by enzyme-linked immunosorbent assay. Computed tomography scans were used at mean age 22 to compute subcutaneous and visceral abdominal fat volume. Partial Pearson correlations and linear regression were used to examine cross-sectional associations at each examination. Results The moderate negative correlation between waist circumference and adiponectin was significant and essentially unchanged from mean age 15 (-0.32, P?
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