Antioxidant Systems in Tumour Cells: The Levels of Antioxidant Enzymes, Ferritin, and Total Iron in a Human Hepatoma Cell Line |
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| Authors: | W H Bannister G Federici J K Heath J V Bannister B Halliwell |
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| Institution: |
a Nuffield Dept. of Clinical Biochemistry, Radcliffe Infirmary, University of Oxford, Oxford, England
b Dept, of Biology, II University of Rome, Rome, Italy
c Dept. of Zoology, University of Oxford, Oxford, England
d Inorganic Chemistry Laboratory, University of Oxford, Oxford, England |
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| Abstract: | The human hepatoma cell line Hep 3B, which has the hepatitis B virus genome, shows over 80% decrease of copper/zinc superoxide dismutase activity, over 90% decrease of manganese superoxide dismutase activity, over 70% decrease of catalase activity, absence of glutathione peroxidase and glutathione S-transferase activities, over 270-fold increase of ferritin content and 25-fold increase of total iron compared to normal autopsy liver. These conditions of low antioxidant enzyme activities and iron overload are those which support the accumulation of oxygen free-radicals and DNA damage commonly considered to be carcinogenic mechanisms. |
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| Keywords: | Human Hepatoma Superoxide Dismutase Catalase Glutathione Peroxidase Glutathione S-Transferase Ferritin Iron |
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