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Demonstration of the presence of G-proteins in hepatic microsomal fraction
Authors:J Codina  S Kimura  N Kraus-Friedmann
Affiliation:Department of Cell Biology, Baylor College of Medicine, Houston, Texas.
Abstract:The presence of G-proteins in isolated hepatic microsomal vesicles is demonstrated. The G-proteins were identified by their capacity to be ADP-ribosylated by cholera and pertussis toxins. Cholera toxin identified 42 and 45 kDa proteins, corresponding to alpha s-1 and alpha s-2, respectively. Pertussis toxin identified a 40 kDa protein corresponding to alpha i. The microsomal G-proteins are identical to the corresponding G proteins of the plasma membrane, but are present in different proportions; the microsomes have considerably less alpha s proteins than the plasma membrane.
Keywords:
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