An NMR spectroscopic identity test for the control of the capsular polysaccharide from Haemophilus influenzae type b. |
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| Authors: | X Lemercinier C Jones |
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| Institution: | Laboratory for Molecular Structure, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Herts, EN6 3QG, UK. |
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| Abstract: | We describe the use of Nuclear Magnetic Resonance (NMR) spectroscopy to control the identity of purified bulk capsular polysaccharide called poly(ribosylribitolphosphate) or PRP] from Haemophilus influenzae type b (Hib), and derivatised forms, used in the production of Hib polysaccharide-protein conjugate vaccines. We describe the approaches we have developed to validate this test. |
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