Analysis of nucleolar organizing regions in parents of trisomic spontaneous abortions |
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Authors: | Terry Hassold Patricia A Jacobs Dorothy Pettay |
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Institution: | (1) Division of Human Genetics Department of Pediatrics, Cornell University Medical College, 10021 New York, NY, USA |
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Abstract: | Summary Nucleolar organizing region (NOR) variants of parents of karyotyped spontaneous abortions were examined to fest the hypothesis that double NORs are important in the genesis of acrocentric trisomies. We were unable to detect any significant difference in the frequency or types of NOR variants between parents of acrocentric trisomies and parents of other types of spontaneous abortions, nor did we identify a double NOR in either group. Thus, it seems unlikely that double NORs are of major significance in the etiology of acrocentric trisomies. |
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