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Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine |
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| Authors: | Aslanian Robert Mutahi Mwangi wa Shih Neng-Yang Piwinski John J West Robert Williams Shirley M She Susan Wu Ren-Long Hey John A |
| Affiliation: | The Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. robert.aslanian@spcorp.com |
| Abstract: | Combining the first generation H(1) antihistamine chlorpheniramine (1) with H(3) ligands of the alkylamine type has led to the identification of compound 9d, a dual ligand of both the H(1) and H(3) receptors. |
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