Kinetics of c2-repressor synthesis in a regulatory defective P22 mutant |
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Authors: | H. H. Prell and A. M. Harvey |
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Affiliation: | (1) Abt. für Molekulare Genetik der Gesellschaft für Strahlen-und Umweltforschung mbH München in Göttingen, D-3400 Göttingen, Federal Republic of Germany |
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Abstract: | Summary Phage P22 defective in gene 24 and harbouring the oc mutation k5 in OR exhibits a strongly increased c2-repressor synthesis after infection of non-lysogenic S. typhimurium. The repressor synthesis depends strictly on an intact c1 gene. The kinetics of its synthesis, as monitored by polyacrylamid gel electrophoresis, is the same as with P22 c+, namely a turn off 8–10 min after infection. — After infection of P22-lysogenic bacteria with either P22 24–k5 or P22 24–k5 cl, much lower amounts of repressor are synthesized but again with the same kinetics. These results suggest a cro-like function acting at PRE and PRM of P22. The possible reason for the c2 overproduction is discussed. |
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