Polyclonal B-cell stimulative and immunosuppressive activities at different developmental stages of Trypanosoma gambiense |
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| Authors: | M Oka Y Yabu Y Ito T Takayanagi |
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| Affiliation: | Department of Parasitology, School of Medicine, University of Tokushima. |
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| Abstract: | Bloodstream trypomastigote and cultured procyclic (insect midgut) forms of a monomophic strain of Trypanosoma gambiense were tested for their abilities to induce polyclonal B-cell activation (PBA) and immunosuppression (IS) in mice. Injection of a cell homogenate of bloodstream trypomastigotes induced both PBA and IS, while neither PBA nor IS was observed in mice injected with a cell homogenate of cultured procyclics. The results indicate that the substance(s) inducing PBA or IS is related to the developmental stage of the parasites. |
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