Analysis of allele fidelity, polymorphic information content, and density of microsatellites in a genome-wide screening for hip dysplasia in a crossbreed pedigree |
| |
Authors: | Mateescu R G Zhang Z Tsai K Phavaphutanon J Burton-Wurster N I Lust G Quaas R Murphy K Acland G M Todhunter R J |
| |
Affiliation: | Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, NY 14853, USA. |
| |
Abstract: | Recent advances in genomics resources and tools are facilitating quantitative trait locus mapping. We developed a crossbreed pedigree for mapping quantitative trait loci for hip dysplasia in dogs by crossing dysplastic Labrador Retrievers and normal Greyhounds. We show that one advantage to using a crossbreed pedigree is the increased marker informativeness in the backcross/F2 population relative to the founder populations. We also discuss three factors that affect the detection power in the context of this crossbreed pedigree: being able to detect and correct genotyping errors, increasing marker density for chromosomes with a sparse coverage, and adding individuals to the mapping population as soon as they become available. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|