An image contrast agent selectively activated by prostate specific antigen |
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| Authors: | Jones Graham B Crasto Curtis F Mathews Jude E Xie Longfei Mitchell Miguel O El-Shafey Ahmed D'Amico Anthony V Bubley Glenn J |
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| Institution: | Bioorganic and Medicinal Chemistry Laboratories, Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA. gr.jones@neu.edu |
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| Abstract: | A family of image contrast agent conjugates designed to undergo enzymatic activation has been synthesized. The agents underwent activation both with enzymatically active prostate specific antigen (PSA) and alpha-chymotrypsin, releasing free fluorophore via cleavage of a three-component system. A hexapeptide derivative showed exclusive activation by PSA and constitutes a method for tracking PSA activity in vitro. |
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