Effects of prostaglandin E1 and adrenaline on the pulmonary vascular resistance (PVR) in isolated rabbit lungs |
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| Authors: | A Hauge P K Lunde B A Waaler |
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| Affiliation: | 1. Research, Central Texas Veterans Health Care System, United States of America;2. Department of Medical Physiology, Texas A&M University, College of Medicine, United States of America;3. Richard L. Roudebush VA Medical Center, Research, United States of America;4. Indiana University, Gastroenterology, Medicine, United States of America;5. Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy;6. Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States of America;7. Department of Nutrition and Food Science, Texas A&M University, College Station, TX, United States of America;8. Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy;9. Digestive Disease Section, Yale University School of Medicine, New Haven, CT, United States of America;10. Humanitas Clinical and Research Center, Rozzano, Milan, Italy;11. Department of Pathophysiology, Key Lab for Shock and Microcirculation Research of Guangdong Province, Southern Medical University, Guangzhou, PR China;1. Pharmacy Laboratory, Faculty of Chemical Sciences, Autonomous University of San Luis Potosi, Mexico;2. Hospital Central “Dr. Ignacio Morones Prieto”, Manuel Nava Martínez Ave. #6, University area, C.P, 78210 San Luis Potosi, Mexico;1. Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan;2. Neonatology, National Center for Child Health and Development, Setagaya, Japan;3. Department of Data Science, Clinical Research Center, National Center for Child Health and Development, Setagaya, Japan;4. Neonatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;5. Neonatology, Osaka City General Hospital, Osaka, Japan;6. Pediatrics, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan;7. Neonatology, Kanagawa Children''s Medical Center, Yokohama, Japan |
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| Abstract: | Injections of from 1 to 50 μg of prostaglandin E1 (PGE1) almost invariably, caused vasodilatation in the pulmonary vascular bed of an isolated rabbit lung preparation. The same effect was usually obtained by injections of from 0.5 to 50 ωg of adrenaline. On a weight basis the two substances were about equally potent as pulmonary vasodilators, but large individual variations in responses were seen. Addition to the perfusate of adrenergic α- and β-inhibitors (phentolamine and propranolol, respectively), in doses high enough to abolish the responses to adrenaline, did hardly affect the responses to PGE1. The two substances do apparently have different sites of action in the rabbit pulmonary vascular bed. |
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