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Phylogenetic analysis of the first complete hepatitis E virus (HEV) genome from Africa
Authors:van Cuyck Hélène  Juge François  Roques Pierre
Affiliation:Weapons of Mass Destruction Centre (WMD Centre), NATO, AB310, Bd. Leopold III, 1110, Brussels, Belgium. h.vancuyck@skynet.be
Abstract:Hepatitis E virus (HEV) is globally distributed, transmitted enterically and between humans and animals. Phylogenetic analysis has identified five distinct HEV genotypes. The first full-length sequence of an African strain (Chad) is presented and compared to 31 complete HEV genomes available, including the fulminant hepatitis strain from India, swine strains and a strain from Morocco. The two African strains are more closely related to genotype 1 than to any other genotypes and together they possibly form a sub-genotype or sixth genotype. The first evidence for recombination between divergent HEV strains is presented.
Keywords:Hepatitis E virus    Hepatitis E virus genome sequence    Phylogenetic analysis    Recombination
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