Regulation of eukaryotic DNA replication and nuclearstructure |
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Authors: | WU JIA RUI |
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Affiliation: | Shanghai Institute of Biochemistry, Chinese Academy of Sciences, USA. wujr@sunm.shcnc.ac.cn |
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Abstract: | In eukaryote, nuclear structure is a key component forthe functions of eukaryotic cells. More and more evidencesshow that the nuclear structure plays important role in re-gulating DNA replication. The nuclear structure providesa physical barrier for the replication licensing, participatesin the decision where DNA replication initiates, and orga-nizes replication proteins as replication factory for DNAreplication. Through these works, new concepts on theregulation of DNA replication have emerged, which willbe discussed in this minireview. |
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Keywords: | DNA replication nuclear structure replication licensing replication origin replication factory |
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