Molecular probe for selective detection of thiols in water of neutral pH |
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Authors: | Kim Dong H Han Min Su |
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Institution: | Center for Integrated Molecular Systems and Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31 Hyoja-dong, Pohang 790-784, South Korea. dhkim@postech.ac.kr |
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Abstract: | The ternary complex, Zn(cyclen)(lumazine)](+) that can be readily obtained by mixing cyclen, zinc perchlorate, and lumazine in water in a 1:1:1 molar ratio serves as a molecular probe that detects selectively thiols in an aqueous solution of neutral pH. Thiols successfully displace the lumazine in the molecular probe, which is accompanied by a decrease of the fluorescence. The molecular probe is useful for identification of cysteine among essential amino acids and detection of glutathione in aqueous solution of neutral pH. |
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