|
|||||
|
|
Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24 |
|
| Authors: | Schumacher Johannes Kaneva Radka Jamra Rami Abou Diaz Guillermo Orozco Ohlraun Stephanie Milanova Vihra Lee Young-Ae Rivas Fabio Mayoral Fermin Fuerst Robert Flaquer Antonia Windemuth Christine Gay Eudoxia Sanz Sebastian González Maria José Gil Susana Cabaleiro Francisco del Rio Francisco Perez Fermin Haro Jesus Kostov Christian Chorbov Vesselin Nikolova-Hill Amelia Stoyanova Vessela Onchev George Kremensky Ivo Strauch Konstantin Schulze Thomas G Nürnberg Peter Gaebel Wolfgang Klimke Ansgar Auburger Georg Wienker Thomas F Kalaydjieva Luba Propping Peter Cichon Sven Jablensky Assen |
| Affiliation: | 1 Institute of Human Genetics, University of Bonn, Bonn 2 Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn 3 Department of Genomics, Life &; Brain Center, University of Bonn, Bonn 4 Laboratory of Molecular Pathology, Medical University, Sofia, Bulgaria 5 Department of Psychiatry, Medical University, Sofia, Bulgaria 6 Civil Hospital Carlos Haya, Málaga, Spain 7 Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, Mannheim, Germany 8 Max Delbrück Center for Molecular Medicine, Berlin 9 University Hospital Reina Sofía, 10 Mental Health Care Centre Lucena, Spain 11 Mental Health Care Centre Montoro, Córdoba, Spain 12 Province Hospital, Jaén, Spain 13 Mental Health Care Centre de San Dionisio Jerez de la Frontera Cádiz, Spain 14 URA, Puerto de Santamaría Cádiz, Spain 15 Mental Health Care Centre Algeciras Cádiz, Cádiz, Spain 16 Newcastle Regional Mental Health Services, Newcastle, Australia 17 Institute for Medical Biometry and Epidemiology, Phillipps University Marburg, Marburg, Germany 18 Department of Psychiatry, University of Düsseldorf, Düsseldorf 19 Clinic for Neurology, University of Frankfurt, Frankfurt 20 Western Australian Institute for Medical Research and Centre for Medical Research, Perth 21 School of Psychiatry and Clinical Neurosciences, The University of Western Australia, Perth |
| Abstract: | We present the findings of a large linkage study of bipolar affective disorder (BPAD) that involved genomewide analysis of 52 families (448 genotyped individuals) of Spanish, Romany, and Bulgarian descent and further fine mapping of the 1p34-p36, 4q28-q31, and 6q15-q24 regions. An additional sample of 56 German families (280 individuals) was included for this fine-mapping step. The highest nonparametric linkage scores obtained in the fine mapping were 5.49 for 4q31 and 4.87 for 6q24 in the Romany families and 3.97 for 1p35-p36 in the Spanish sample. MOD-score (LOD scores maximized over genetic model parameters) analysis provided significant evidence of linkage to 4q31 and at least borderline significance for the 1p and 6q regions. On the basis of these results and previous positive research findings, 4q31 and 6q24 should now be considered confirmed BPAD susceptibility loci, and 1p35-p36 is proposed as a new putative locus that requires confirmation in replication studies. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |