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Abdominal vagotomy does not block the satiety effect of bombesin in the rat |
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| Authors: | GP Smith C Jerome and J Gibbs |
| Institution: | aEdward W. Bourne Behavioral Research Laboratory, Department of Psychiatry Cornell University Medical College, White Plains, NY 10605, USA bThe New York Hospital, White Plains, NY 10605, USA |
| Abstract: | Bombesin (2-16 microgram-kg-1, intraperitoneally) inhibited food intake in rats after abdominal vagotomy. Since the same vagotomized rats did not respond to the octapeptide of cholecystokinin (1-8 micrograms-kg-1, intraperitoneally), these data are decisive evidence (1) that bombesin does not produce satiety by releasing endogenous cholecystokinin and (2) that vagal afferents are not necessary for the satiety effect of bombesin. |
| Keywords: | Bombesin Chlecystokinin Satiety Food intake Vagotomy Inhibition of food intake Gut peptides Peptide hormones Gut hormones |
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