Streptococcal collagen-like surface protein 1 promotes adhesion to the respiratory epithelial cell |
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| Authors: | Shih-Ming Chen Yau-Sheng Tsai Chin-Ming Wu Shuen-Kuei Liao Ling-Chia Wu Cherng-Shyang Chang Ya-Hui Liu Pei-Jane Tsai |
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| Affiliation: | 1.Graduate Institute of Clinical Medical Sciences,Chang Gung University,Taoyuan,ROC;2.Institute of Clinical Medicine, College of Medicine,National Cheng Kung University,Tainan,Taiwan ROC;3.Department of Cell Biology and Anatomy, College of Medicine,National Cheng Kung University,Tainan,Taiwan ROC;4.Department of Medical Laboratory Science and Biotechnology, College of Medicine,National Cheng Kung University,Tainan,Taiwan ROC;5.Institute of Basic Medical Sciences, College of Medicine,National Cheng Kung University,Tainan,Taiwan ROC |
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| Abstract: | Background Collagen-like surface proteins Scl1 and Scl2 on Streptococcus pyogenes contain contiguous Gly-X-X triplet amino acid motifs, the characteristic structure of human collagen. Although the potential role of Scl1 in adhesion has been studied, the conclusions may be affected by the use of different S. pyogenes strains and their carriages of various adhesins. To explore the bona fide nature of Scl1 in adherence to human epithelial cells without the potential interference of other streptococcal surface factors, we constructed a scl1 isogenic mutant from the Scl2-defective S. pyogenes strain and a Scl1-expressed Escherichia coli. |
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