Phosphoinositide 3-kinase inhibition enables retinoic acid-induced neurogenesis in monolayer culture of embryonic stem cells |
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Authors: | Kotasová Hana Veselá Iva Kučera Jan Houdek Zbyněk Procházková Jiřina Králičková Milena Pacherník Jiří |
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Institution: | Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic. |
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Abstract: | Retinoic acid (RA) is able to induce the differentiation of embryonic stem cells into neuronal lineages. The mechanism of this effect is unknown but it has been evidenced to be dependent on the formation of floating spheroids called embryoid bodies. Results presented here show that the inhibition of phosphoinositide 3-kinase signaling pre-determines mouse embryonic stem cells to RA induced neurogenesis in monolayer culture with no need of embryoid bodies formation. |
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Keywords: | EMBRYONIC STEM CELL RETIONIC ACID NEUROGENESIS DIFFERENTIATION |
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