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Homozygosity mapping of the locus responsible for renal tubular dysplasia of cattle on bovine Chromosome 1
Authors:Yasunori Ohba  Hitoshi Kitagawa  Katsuya Kitoh  Sachiyo Asahina  Kaori Nishimori  Kazuhiro Yoneda  Tetsuo Kunieda  Yoshihide Sasaki
Affiliation:(1) Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, Yanagido, Gifu 501-1193, Japan, JP;(2) Department of Biological Function, Faculty of Agriculture, Okayama University, Okayama 700-8530, Japan, JP
Abstract:Renal tubular dysplasia is a hereditary disease of Japanese black cattle showing renal failure and growth retardation with an autosomal recessive trait. In the present study, we mapped the locus responsible for the disease (RTD) by linkage analysis with an inbred paternal half-sib pedigree obtained from commercial herds. By analyzing segregation of microsatellite markers in the half-sibs, significant linkage was observed between the RTD locus and markers on bovine Chromosome (Chr) 1 with the highest lod score of 11.4. Homozygosity mapping with the inbred pedigree further defined the localization of the RTD locus in a 4-cM region between microsatellite markers BMS4003 and INRA119. Mapping of the RTD locus on bovine Chr 1 will facilitate cloning and characterization of the gene responsible for this disease. Received: 24 September 1999 / Accepted: 14 December 1999
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