Gamma delta TCR cells in hepatic sinusoids and intestinal intraepithelia

We provided here the conception that the liver is an important immune organ after birth. On the other hard, it is well established that the liver in the fetal stage works as a hematopoietic organ. Although a significant number of gamma delta TCR cells are distributed in epithelia of the skin, intestine and reproductive organs, the liver is also one of the most predominant organs of gamma delta TCR cells. The percentages of gamma delta TCR cells in MNC of hepatic sinusoids increased up to 16.0% in young mice aged 4 wk, and approximately 40% of such gamma delta TCR cells expressed the CD8 antigens. V gene segment usage analysis by the PCR method demonstrated that a unique set of V gamma 2/V delta 6 was preferentially used by hepatic gamma delta TCR cells. The predominant appearance of unique gamma delta TCR cells in hepatic sinusoids of mice, including nude mice, proposed us the possibility that these gamma delta TCR cells may differentiate non-thymus dependently in the liver. The lymphocytes in the hepatic sinusoids may be intimately related to the antigens come from the intestine and to the lymphocytes sensitized there. Therefore, we introduced recent evidences about gamma delta T cells in the intestine and discussed their connection with the hepatic gamma delta T cells.