Hepatic heme metabolism in selenium-deficient rats: effect of phenobarbital. |
| |
| Authors: | M A Correia R F Burk |
| |
| Affiliation: | 1. Liver Unit, Department of Internal Medicine University of Texas Health Science Center Southwestern Medical School Dallas, Texas 75235 USA;2. Veterans Administration Hospital Dallas, Texas 75235 USA |
| |
| Abstract: | Hepatic heme metabolism was examined in selenium (Se)-deficient and Se-adequate (control) rats. Administration of phenobarbital stimulated heme synthesis in the liver in both Se-deficient and Se-adequate rats. In contrast to these results, phenobarbital increased microsomal heme oxygenase (MHO) activity six- to eightfold in Se-deficient but not control rats. These data suggest that the previously reported abnormalities of cytochrome P-450 induction in Se-deficient rats are related to increased degradation of hepatic heme. |
| |
| Keywords: | To whom all correspondence should be addressed. |
| 本文献已被 ScienceDirect 等数据库收录！ |
