Antimicrobial activity of trialkylgermanium acetates and the influence of the medium |
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| Authors: | Antje Kaars Sijpesteijn F Rijkens G J M van der Kerk A Manten |
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| Institution: | (1) Institute for Organic Chemistry T.N.O., Utrecht, The Netherlands;(2) National Institute of Public Health, Utrecht, The Netherlands |
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| Abstract: | A continued study of the antimicrobial activity of a series of trialkylgermanium acetates has confirmed earlier findings that the most active compounds against fungi are the ethyl and propyl derivatives, whereas for optimum antibacterial activity the chain length has to be somewhat greater. All fungi but only a few of the bacteria tested appear to be sensitive.Incorporation of blood in the medium abolishes antibacterial activity but leaves antifungal activity unaltered. |
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