Antitumor effects of snake venom chemically modified Lys49 phospholipase A2-like BthTX-I and a synthetic peptide derived from its C-terminal region |
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Authors: | Luiz Carlos Gebrim Silvana Marcussi Danilo L Menaldo Carla SR de Menezes Auro Nomizo Amlia Hamaguchi Elisngela P Silveira-Lacerda Maria Inês Homsi-Brandeburgo Suely V Sampaio Andreimar M Soares Veridiana M Rodrigues |
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Institution: | Luiz Carlos Gebrim, Silvana Marcussi, Danilo L. Menaldo, Carla S.R. de Menezes, Auro Nomizo, Amélia Hamaguchi, Elisângela P. Silveira-Lacerda, Maria Inês Homsi-Brandeburgo, Suely V. Sampaio, Andreimar M. Soares,Veridiana M. Rodrigues, |
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Abstract: | The present work evaluates both in vitro and in vivo antitumor activity of BPB-modified BthTX-I and its cationic synthetic peptide derived from the 115–129 C-terminal region. BPB-BthTX-I presented cytotoxicity of 10–40% on different tumor cell lines, which were also susceptible to the lytic action of the synthetic peptide. Injection of the modified protein or the peptide in mice, 5 days after transplantation of S180 tumor cells, reduced 30 and 36% of the tumor size on day 14th and 76 and 79% on day 60th, respectively, when compared to the untreated control group. Thus, these antitumor properties might be of interest in the development of therapeutic strategies against cancer. |
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Keywords: | BthTX-I Bothrops jararacussu Chemical modification BPB Synthetic peptide Antitumor activity |
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