Synthesis of marine alkaloid: 8,9-dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents |
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| Authors: | Gupta Leena Talwar Archna Nishi Palne Shraddha Gupta Suman Chauhan Prem M S |
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| Affiliation: | Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India. |
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| Abstract: | A series of marine alkaloid 8,9-dihydrocoscinamide B, its analogues and indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 7 and 10 have shown 99-100% inhibition against promastigotes and 97-98% inhibition against amastigotes at a concentration of 10 microg/ml. |
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