Autologous responses to human leukaemic cells in mixed leucocyte culture |
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| Authors: | Leonie K Ashman Denise E O'Keefe Christopher A Juttner R G Toogood Michael S Rice |
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| Institution: | (1) Department of Microbiology and Immunology, The University of Adelaide, GPO Box 498, 5001 Adelaide, S. A., Australia;(2) Division of Haematology, Institute of Medical and Veterinary Sciences, Adelaide, South Australia;(3) Oncology Unit, Adelaide Children's Hospital, Adelaide, South Australia |
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| Abstract: | Summary Cryopreserved leukaemic blasts and remission non-T cells from 22 patients with acute leukaemia (15 lymphocytic, 7 non-lymphocytic) were tested as stimulators of autologous remission T cells and normal allogeneic T cells in primary and secondary MLC. In most cases the autologous response elicited by leukaemic cells was less than or equal to that elicited by remission non-T cells. However, T cells from 2 patients in long-standing first remission from ANLL displayed greater proliferation in response to leukaemic blasts than to remission non-T cells in both primary and secondary MLC. The results are suggestive of sensitization of these 2 patients to leukaemia-specific antigens, but other possible explanations are discussed.
Abbreviations used: MLC, mixed leucocyte culture; ANLL, acute non-lymphocytic leukaemia; ALL, acute lymphoblastic leukaemia; AMLR, autologous mixed lymphocyte reaction; NK cells, natural killer cells; MNC, mononuclear cells |
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